Structure of PDB 5zsm Chain A

Receptor sequence

>5zsmA (length=774) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPQVLEQLYYFRYDKYARSCRSCYKYGQTLDLSKNSIFFIKSS
DFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTA
FEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSS
TSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNS
LSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQL
TTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQM
IQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATD
VTCVGPGAHKGQSVISLDLYTCEL

3D structure

• PDB: 5zsm To be published
• Chain: A
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	H76 C98 L105 D135 E156 Q181 Y184 R186 R467 A472 R473 S474 C475	H50 C72 L79 D109 E130 Q155 Y158 R160 R419 A424 R425 S426 C427
BS02	rna	A	H630 D632 R636	H569 D571 R575
BS03	9K9	A	T532 D555 L557 G584 I585 T586	T471 D494 L496 G523 I524 T525
BS04	9K9	A	Y264 F351 Q354 Y356 F408	Y238 F325 Q328 Y330 F382

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zsm, PDBe:5zsm, PDBj:5zsm
• PDBsum: 5zsm
• PubMed: 30566863
• UniProt: B3Y653