Structure of PDB 5zse Chain A

Receptor sequence

>5zseA (length=774) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPVLEQLYYFRYDKYARSCRFSCYKYGQTLDLSKNSIFFIKSS
DFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTA
FEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSS
TSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNS
LSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQL
TTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQM
IQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATD
VTCVGPGAHKGQSVISLDLYTCEL

3D structure

• PDB: 5zse To be published
• Chain: A
• Resolution: 2.201 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	I74 H76 L105 G106 S107 D135 E156 Q181 Y184 R186 R467 D469 A472 R473 S474 C475	I48 H50 L79 G80 S81 D109 E130 Q155 Y158 R160 R418 D420 A423 R424 S425 C426
BS02	rna	A	H630 D632 V633 R636	H569 D571 V572 R575
BS03	IDQ	A	F351 Q354 V355 Y356 F408	F325 Q328 V329 Y330 F382
BS04	IDQ	A	D555 L557 G584 T586	D494 L496 G523 T525

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zse, PDBe:5zse, PDBj:5zse
• PDBsum: 5zse
• PubMed: 30566863
• UniProt: B3Y653