Structure of PDB 5zsd Chain A

Receptor sequence

>5zsdA (length=773) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPVLEQLYYFRYDKYARSCRSCYKYGQTLDLSKNSIFFIKSSD
FQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAF
EELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSST
SRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSL
SFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLT
TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI
QKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATDV
TCVGPGAHKGQSVISLDLYTCEL

3D structure

• PDB: 5zsd To be published
• Chain: A
• Resolution: 2.603 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	I74 H76 C98 L105 S107 D135 E156 Q181 Y184 R186 R467 Y468 D469 A472 R473 S474 C475	I48 H50 C72 L79 S81 D109 E130 Q155 Y158 R160 R418 Y419 D420 A423 R424 S425 C426
BS02	IDQ	A	F351 Q354 V355 Y356 F408	F325 Q328 V329 Y330 F382
BS03	IDQ	A	D555 L557 G584 I585 T586	D493 L495 G522 I523 T524

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zsd, PDBe:5zsd, PDBj:5zsd
• PDBsum: 5zsd
• PubMed: 30566863
• UniProt: B3Y653