Structure of PDB 5zq8 Chain A

Receptor sequence

>5zq8A (length=454) Species: 170187 (Streptococcus pneumoniae TIGR4)

MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMRVLKVNK
KIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVK
DSLYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNS
HNLMPLEDFFIQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVR
RGHYSGQIMVVLVTTRPKVFRVDQLIEQVIKQFPEIVSVMQNINDQNTNA
IFGKEWRTLYGQDYITDQMLGNDFQIAGPAFYQVNTEMAEKLYQTAIDFA
ELKKDDVIIDAYSGIGTIGLSVAKHVKEVYGVELIPEAVENSQKNASLNK
ITNAHYVCDTAENAMKKWLKEGIQPTVILVDPPRKGLTESFIKASAQTGA
DRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVQTVALLSK
LDVD

3D structure

• PDB: 5zq8 Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
• Chain: A
• Resolution: 2.18 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	G79 R127 K129 A130 Q131 P133 F145 F146 K148 N149 S150 H151 I161 Q162 E187 N249 I251 F281 Q283 D381 P382 R384 K385 C408 F436 H441 Q443	G79 R127 K129 A130 Q131 P133 F145 F146 K148 N149 S150 H151 I161 Q162 E187 N249 I251 F281 Q283 D381 P382 R384 K385 C408 F436 H441 Q443
BS02	SAH	A	F281 Y293 Y312 S313 T317 A361 D381	F281 Y293 Y312 S313 T317 A361 D381

Gene Ontology

Molecular Function

• GO:0008173 RNA methyltransferase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:5zq8, PDBe:5zq8, PDBj:5zq8
• PDBsum: 5zq8
• PubMed: 30388185
• UniProt: Q97R12|Y1029_STRPN Uncharacterized RNA methyltransferase SP_1029 (Gene Name=SP_1029)