Structure of PDB 5zof Chain A

Receptor sequence
>5zofA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKVKVTKQHNDECKH
LLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMACLTFGSPVLMFH
LTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGP
KRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPES
VELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQ
3D structure
PDB5zof Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
ChainA
Resolution2.249 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A A45 V46 R70 K200 R239 G240 I241 G242 K244 R245 A44 V45 R69 K157 R196 G197 I198 G199 K201 R202
BS02 dna A L53 Q54 T61 K314 Q315 F316 S317 L52 Q53 T60 K271 Q272 F273 S274
BS03 dna A I44 R47 I43 R46
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5zof, PDBe:5zof, PDBj:5zof
PDBsum5zof
PubMed30295841
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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