Structure of PDB 5zoe Chain A

Receptor sequence
>5zoeA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKVKVTKQHNDECKH
LLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMACLTFGSPVLMRH
LTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGP
KRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPES
VELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQ
3D structure
PDB5zoe Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A A45 V46 M65 Y69 R70 R73 K200 R239 G240 G242 K244 R245 R327 A44 V45 M64 Y68 R69 R72 K157 R196 G197 G199 K201 R202 R284
BS02 dna A Q48 L53 Q54 T61 M65 K314 Q315 F316 S317 R320 Q47 L52 Q53 T60 M64 K271 Q272 F273 S274 R277
BS03 dna A I44 R47 G50 I43 R46 G49
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5zoe, PDBe:5zoe, PDBj:5zoe
PDBsum5zoe
PubMed30295841
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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