Structure of PDB 5zo9 Chain A

Receptor sequence
>5zo9A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
MKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTSSRKTYTFDMV
FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSP
NEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDL
LNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKR
TTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSEN
NINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATI
SPASLNLEETLSTLEYAHRAKNILNKPEVNQ
3D structure
PDB5zo9 Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors.
ChainA
Resolution2.7 Å
3D
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 R26 T107 G108 G110 K111 T112 F113 E118 R9 R11 T86 G87 G89 K90 T91 F92 E97
BS02 4C5 A E116 G117 E118 I136 P137 Y211 L214 E95 G96 E97 I115 P116 Y190 L193 PDBbind-CN: -logKd/Ki=8.20,Kd=6.3nM
BindingDB: Ki=22nM,IC50=28.5nM,EC50=230nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:5zo9, PDBe:5zo9, PDBj:5zo9
PDBsum5zo9
PubMed31459302
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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