Structure of PDB 5zln Chain A

Receptor sequence

>5zlnA (length=751) Species: 10090 (Mus musculus) [Search protein sequence]

TLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHH
LHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEE
LNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGN
CYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLV
SYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHP
ETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNMSVLDLSENFLYESIQHT
NAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFR
SLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRI
SGPSTKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSI
AQAVQGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQP
FSMKGIGHNFSFVAHLSMLHSLSLAHNDIHTRVSSHLNSNSVRFLDFSGN
GMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLL
SLRDNYLSFFQWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDV
SSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVR
SNPLHCACGAAFVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRL
C

3D structure

PDB

5zln Structural basis for species-specific activation of mouse Toll-like receptor 9

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W47 S72 R74 H76 H77 W96 P99 S104 P105 L106 F108 Y180 Y208 P262 N263	W20 S45 R47 H49 H50 W69 P72 S77 P78 L79 F81 Y153 Y181 P235 N236
BS02	dna	A	R613 H642 S667 F668	R554 H583 S608 F609
BS03	dna	A	D259 H260 Y345 K348 V349 S350 F351 A352 R377 F402	D232 H233 Y318 K321 V322 S323 F324 A325 R350 F375
BS04	dna	A	D535 Y537 G566 H567 R591 V592	D476 Y478 G507 H508 R532 V533

External links

PDB	RCSB:5zln, PDBe:5zln, PDBj:5zln
PDBsum	5zln
PubMed	29961984
UniProt	Q9EQU3\|TLR9_MOUSE Toll-like receptor 9 (Gene Name=Tlr9)

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