Structure of PDB 5zlf Chain A

Receptor sequence
>5zlfA (length=293) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMI
AVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANA
AFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQLM
NVNITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLG
TAFQLIDDLLDYNNVGDDLNEGKPTLPLLHQAQMIRTAIEQGNGRHLLEP
VLEAMEWTRQRAEEEADKAIAALQVLPDTPWREALIGLAHIAV
3D structure
PDB5zlf Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
ChainA
Resolution2.845 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.90: all-trans-octaprenyl-diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B29 A T80 D84 R93 I142 A143 E146 T79 D83 R92 I141 A142 E145 PDBbind-CN: -logKd/Ki=3.48,IC50~330uM
BS02 MG A D84 D88 D83 D87
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0106350 octaprenyl pyrophosphate synthase activity
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016094 polyprenol biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zlf, PDBe:5zlf, PDBj:5zlf
PDBsum5zlf
PubMed30730737
UniProtP0AD57|ISPB_ECOLI Octaprenyl diphosphate synthase (Gene Name=ispB)

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