Structure of PDB 5zkj Chain A

Receptor sequence
>5zkjA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
SAEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMG
DADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMA
ETFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTR
GDGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEA
IGFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQ
EFTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLE
3D structure
PDB5zkj A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainA
Resolution2.798 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C57 A85 N107 N116 E124
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R109 K110 S137 R138 A144 G145 K148 F168 N171 S172 N176 R183 R314 R54 K55 S82 R83 A89 G90 K93 F113 N116 S117 N121 R128 R259 PDBbind-CN: Kd=0.19uM
BS02 dna A K115 S172 L311 R320 R324 K327 K60 S117 L256 R265 R269 K272 PDBbind-CN: Kd=0.19uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5zkj, PDBe:5zkj, PDBj:5zkj
PDBsum5zkj
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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