Structure of PDB 5zki Chain A

Receptor sequence
>5zkiA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
EKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDA
DRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAET
FYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGD
GKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIG
FQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEF
TLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKAK
3D structure
PDB5zki A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainA
Resolution2.321 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C55 A83 N105 N114 E122
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R109 S137 R138 G139 A144 G145 F168 N171 S172 N176 Y310 R314 R52 S80 R81 G82 A87 G88 F111 N114 S115 N119 Y253 R257 PDBbind-CN: Kd=1.32uM
BS02 dna A S172 L311 K315 R320 R324 S115 L254 K258 R263 R267 PDBbind-CN: Kd=1.32uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5zki, PDBe:5zki, PDBj:5zki
PDBsum5zki
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

[Back to BioLiP]