Structure of PDB 5zk7 Chain A

Receptor sequence
>5zk7A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
ANPEHYIKHPLQNRWALWFFKWQANLRLISKFDTVEDFWALYNHIQLSSN
LMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETL
LCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYK
ERLGLPPKIVIGYQSHADTATTKNRFVV
3D structure
PDB5zk7 Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
ChainA
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L131 E132 L97 E98
BS02 peptide A Y34 H37 P38 L39 Q40 V69 W73 R128 E132 R186 Y6 H9 P10 L11 Q12 V35 W39 R94 E98 R152
BS03 MGT A W56 M101 W102 E103 W22 M67 W68 E69
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zk7, PDBe:5zk7, PDBj:5zk7
PDBsum5zk7
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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