Structure of PDB 5zjy Chain A

Receptor sequence
>5zjyA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
HYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLS
SNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLE
TLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRV
YKERLGLPPKIVIGYQSHADTATTKNRFVV
3D structure
PDB5zjy Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H37 P38 L39 Q40 V69 W73 E132 L135 G139 D143 H5 P6 L7 Q8 V37 W41 E100 L103 G107 D111
BS02 MGP A W56 M101 W102 E103 R157 K162 W24 M69 W70 E71 R125 K130 BindingDB: Ki=28nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zjy, PDBe:5zjy, PDBj:5zjy
PDBsum5zjy
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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