Structure of PDB 5zgc Chain A

Receptor sequence
>5zgcA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSQYDLPYPEAIFE
LPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNID
GLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCP
VCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLT
EAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTE
EMRDLVQRETGKL
3D structure
PDB5zgc Crystal Structure of SIRT3 in complex with H4K16bhb peptide
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 F157 R158 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 F36 R37 N98 D100 H117
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F180 Q228 I230 H248 V292 F293 F294 G295 E296 L322 E323 V324 E325 P326 S329 W353 F49 Q97 I99 H117 V161 F162 F163 G164 E165 L191 E192 V193 E194 P195 S198 W222
BS02 ZN A C256 C259 C280 C283 C125 C128 C149 C152
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5zgc, PDBe:5zgc, PDBj:5zgc
PDBsum5zgc
PubMed
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

[Back to BioLiP]