Structure of PDB 5zg3 Chain A

Receptor sequence
>5zg3A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKN
KWWYDKGECG
3D structure
PDB5zg3 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9C6 A I502 P515 F516 S518 S750 K751 N775 I90 P103 F104 S106 S215 K216 N240 MOAD: Ki=0.061uM
BS02 GLU A Y471 T501 R506 G674 S675 T676 E726 Y59 T89 R94 G139 S140 T141 E191
BS03 ZN A E452 H456 E40 H44
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5zg3, PDBe:5zg3, PDBj:5zg3
PDBsum5zg3
PubMed30209408
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

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