Structure of PDB 5zee Chain A

Receptor sequence
>5zeeA (length=295) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
MQFEKVTYIAVPQKYGQKKVGVEEGPKFLEKLGFMNVLEQVAKSVNKKTI
TEPKTPQELGVTNARNLNEVESVNIELRDTIAKEYDVNNLLINIGGDHSI
GLGTIAGVVKAMKPNARVGVVWFDAHPDMNTPENSPSGNIHGMPLACAVG
LGPQRLTSIMPHYITPKDIMYVGIRSIDVGEQFEIQDKHIDHFTAEDVKR
VGMKEVIEAINKKFVDYDVIHLSFDIDGIDPEFILGTGTPVPKGISLEDS
LYFMSEMGKMKKLHSVDIVEYNPKIEEEITGKNVLKCISSLFGIK
3D structure
PDB5zee Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HAR A D124 H126 D128 N130 S137 H141 G142 D225 D124 H126 D128 N130 S137 H141 G142 D225 PDBbind-CN: -logKd/Ki=2.80,IC50=1.57mM
BS02 MN A H98 D124 D128 D225 H98 D124 D128 D225
BS03 MN A D124 H126 D225 D227 D124 H126 D225 D227
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zee, PDBe:5zee, PDBj:5zee
PDBsum5zee
PubMed31199070
UniProtC4LSS0|ARGI_ENTH1 Arginase (Gene Name=ARG)

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