Structure of PDB 5ze6 Chain A

Receptor sequence
>5ze6A (length=315) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPM
IAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATAN
AAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQL
MNVNDPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYG
RYLGTAFQLIDDLLDYNADGNVGDDLNEGKPTLPLLHAMHHGTPEQAQMI
RTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQVLPDT
PWREALIGLAHIAVQ
3D structure
PDB5ze6 Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.90: all-trans-octaprenyl-diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJX A H77 T80 L81 D84 D113 Y116 E146 H77 T80 L81 D84 D113 Y116 E146 PDBbind-CN: -logKd/Ki=3.35,IC50~450uM
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0106350 octaprenyl pyrophosphate synthase activity
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016094 polyprenol biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ze6, PDBe:5ze6, PDBj:5ze6
PDBsum5ze6
PubMed30730737
UniProtP0AD57|ISPB_ECOLI Octaprenyl diphosphate synthase (Gene Name=ispB)

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