Structure of PDB 5zbz Chain A

Receptor sequence
>5zbzA (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
GVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGY
DVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRY
LSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDV
LEVTKKFMRDPIRILVKK
3D structure
PDB5zbz Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling.
ChainA
Resolution1.3086 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAU A G79 G81 Q115 G59 G61 Q95 MOAD: Kd=12.5uM
PDBbind-CN: -logKd/Ki=4.95,Kd=11.1uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5zbz, PDBe:5zbz, PDBj:5zbz
PDBsum5zbz
PubMed31402318
UniProtP60842|IF4A1_HUMAN Eukaryotic initiation factor 4A-I (Gene Name=EIF4A1)

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