Structure of PDB 5z9q Chain A

Receptor sequence
>5z9qA (length=178) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDKEIIVTIHADNSVSVQ
DDGRGIPTGIHPEEGVSAAEVIMTVLGVGVSVVNALSQKLELVIQREGKI
HRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKR
LRELSFLNSGVSIRLRDKRDGKEDHFHY
3D structure
PDB5z9q Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HX4 A N46 A47 V71 D73 I78 I94 V120 T165 N31 A32 V49 D51 I56 I72 V80 T125
BS02 AX7 A R20 H147 E174 R5 H107 E134
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5z9q, PDBe:5z9q, PDBj:5z9q
PDBsum5z9q
PubMed30429968
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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