Structure of PDB 5z9b Chain A

Receptor sequence
>5z9bA (length=186) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHA
DNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHGVGVSVVNALSQKLEL
VIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEF
EYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHY
3D structure
PDB5z9b Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HX3 A N46 A47 E50 V71 D73 V120 T165 V167 N31 A32 E35 V56 D58 V88 T133 V135
BS02 AX7 A R20 H147 E174 R5 H115 E142
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5z9b, PDBe:5z9b, PDBj:5z9b
PDBsum5z9b
PubMed30429968
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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