Structure of PDB 5z79 Chain A

Receptor sequence

>5z79A (length=588) Species: 5855 (Plasmodium vivax) [Search protein sequence]

TPRNIAVLNFGTNDKKNCVTILETALYLTEKYLGKIINSSYIYETVPEYI
VRDISWIGDLIPTVENSRYEESEDLIYECKELEVFLKNEKINESIIREVS
VEDYENEARRIIKRNDEIMKKNLTSYFFNLTVVVRTFVEDPLAMLVILKY
IEQIMKNRMIDIDILFFNNYTIFEKSISLKGEDIYKIITKYIHINHTSDQ
NRLDIIQNLGDKIEFLCIPHVYTKYRYSILLCLNDIIPEYKHSTFEEAIR
STYNSYVESFEEKYHINIRKNNKRLYVLKDKVSYLKERTHIVGILNVNYD
SFSDGGLFVDPVKAVERMFEMASDGASVIDIGGESSAPYVVPNPSVTERD
LVMPVLKLFKEEWHKLECEVGGGAVSSLQGKLQKVRDAKPIISIDTVNYD
LFKECVEGELVDILNDISACTHNPEIIKLLRRKNKFYSVVLMHKRGNPHT
MDKLTNYDDLISDIKRYLEDRLHFLVLNGVPRYRVLFDVGLGFAKKHDQS
IKLLQHIHVYDEYPLFLGYSRKRFIVHCMWRFKMSHMRQDKDQLLYQKNI
CGGLAIASYSFYKKVDLIRVHDVLETKAVLDVLTRIHQ

3D structure

PDB

5z79 Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HH2	A	N342 S347 F348 S381 D454 N474 M501 D547 F552 K581 R697 H699	N296 S301 F302 S335 D395 N415 M442 D488 F493 K522 R569 H571
BS02	APC	A	R204 D207 D209 I210 I259 E260 F261 C263 H266 R272	R158 D161 D163 I164 I213 E214 F215 C217 H220 R226
BS03	PAB	A	F348 S382 A383 P384 G551 F552 K581 R582	F302 S336 A337 P338 G492 F493 K522 R523
BS04	PE0	A	E57 F160 N162 R272 S274	E48 F127 N129 R226 S228

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5z79, PDBe:5z79, PDBj:5z79
PDBsum	5z79
PubMed	30104413
UniProt	A5JZS1

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