Structure of PDB 5z6w Chain A

Receptor sequence
>5z6wA (length=546) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
PALPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALL
VRMVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFG
LLKKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPV
YELRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFR
LRADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLF
QFAQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALARE
ASCAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSE
PCSVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHP
FHSAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSP
FVYWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWP
AQRRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYVRWHVDD
3D structure
PDB5z6w Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A A15 Y21 R65 R69 K70 Y81 L192 A2 Y8 R52 R56 K57 Y68 L179
BS02 dna A K78 K116 K117 R134 K135 L192 I197 Y198 R296 R333 R529 K65 K103 K104 R121 K122 L179 I184 Y185 R283 R320 R516
BS03 MN A E386 D507 E373 D494
BS04 MN A D507 E522 V523 K524 D494 E509 V510 K511
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5z6w, PDBe:5z6w, PDBj:5z6w
PDBsum5z6w
PubMed29514982
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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