Structure of PDB 5z2m Chain A

Receptor sequence
>5z2mA (length=172) Species: 10090 (Mus musculus) [Search protein sequence]
KKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDD
RLVTMQIWDTAGLERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRD
EFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFET
SAKEAINVEQAFQTIARNALKQ
3D structure
PDB5z2m A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning.
ChainA
Resolution2.142 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T22 T40 T18 T36
BS02 GTP A S17 G18 V19 G20 K21 T22 S23 F33 S34 N35 Y37 T40 G66 N125 K126 D128 L129 S155 A156 K157 S13 G14 V15 G16 K17 T18 S19 F29 S30 N31 Y33 T36 G62 N121 K122 D124 L125 S151 A152 K153
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5z2m, PDBe:5z2m, PDBj:5z2m
PDBsum5z2m
PubMed30012887
UniProtP51150|RAB7A_MOUSE Ras-related protein Rab-7a (Gene Name=Rab7a)

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