Structure of PDB 5z12 Chain A

Receptor sequence
>5z12A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGH
SDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPD
RQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFN
HHHAEMLMSWKFTPLLCEIWDVQ
3D structure
PDB5z12 Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P477 E481 P214 E218
BS02 33Y A L301 A305 H308 M342 S346 I349 M379 Y383 L43 A47 H50 M84 S88 I91 M121 Y125 BindingDB: EC50=4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5z12, PDBe:5z12, PDBj:5z12
PDBsum5z12
PubMed29934308
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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