Structure of PDB 5yxl Chain A

Receptor sequence
>5yxlA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
TPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHV
QVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKSDLLEER
IRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR
EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML
MSWRVNDHKFTPLLCEIWDV
3D structure
PDB5yxl A ligand M binding to FXR
ChainA
Resolution2.24 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H70 Q73 L221 H68 Q71 L213
BS02 NIW A F41 L44 T45 F86 S89 Y118 M122 H204 M207 W226 F39 L42 T43 F84 S87 Y110 M114 H196 M199 W218
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5yxl, PDBe:5yxl, PDBj:5yxl
PDBsum5yxl
PubMed
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

[Back to BioLiP]