Structure of PDB 5yx6 Chain A

Receptor sequence
>5yx6A (length=360) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITS
VLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAFR
PGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAG
MTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQV
AMYDVAVGLQANQLMMHLNRTQPSDAFRTADGYIVISAYVPKHWQKLCYL
IGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGL
MACLAHTWKQVVDTPLFAENDLTLEVGTITVIRTPARYASFRAVVTDPPP
TAGEHNAVFL
3D structure
PDB5yx6 Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V22 D146 D175 T248
Catalytic site (residue number reindexed from 1) V18 D142 D171 T221
Enzyme Commision number 2.8.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOL A A102 P143 A98 P139
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:5yx6, PDBe:5yx6, PDBj:5yx6
PDBsum5yx6
PubMed30342240
UniProtP96877|COATR_MYCTU Probable fatty acyl-CoA transferase Rv3272 (Gene Name=Rv3272)

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