Structure of PDB 5ywy Chain A

Receptor sequence
>5ywyA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
NSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLLVTDLL
GTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSRLSIICAMSVER
YLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPD
TWCFIDWTTQVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHAGA
EIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIR
IASVNPILDPWIYILLRKTVLSKAIEKIKC
3D structure
PDB5ywy Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7UR A T76 Y80 W169 L312 I315 R316 S319 V320 T59 Y63 W152 L246 I249 R250 S253 V254 PDBbind-CN: -logKd/Ki=7.23,Kd=59nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004955 prostaglandin receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ywy, PDBe:5ywy, PDBj:5ywy
PDBsum5ywy
PubMed30510193
UniProtP35408|PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (Gene Name=PTGER4)

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