Structure of PDB 5ywv Chain A

Receptor sequence
>5ywvA (length=226) Species: 10090 (Mus musculus) [Search protein sequence]
QTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGH
PPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDN
LAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCV
DSIAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQW
KPQALLQWVDEHARPFSTVKPMYGTP
3D structure
PDB5ywv Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 G23 L24 P25 I84 H124 N125 Y129 I156 S176 Y177 S178 L179 E17 A18 G20 L21 P22 I81 H121 N122 Y126 I153 S166 Y167 S168 L169
BS02 MG A D18 E20 D200 D15 E17 D190
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywv, PDBe:5ywv, PDBj:5ywv
PDBsum5ywv
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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