Structure of PDB 5ywu Chain A

Receptor sequence
>5ywuA (length=225) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASSPRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQ
WKPQALLQWVDEHARPFSTVKPMYG
3D structure
PDB5ywu Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 G23 L24 P25 S26 A81 I84 T85 H124 N125 R128 Y129 S176 S178 L179 E16 A17 G19 L20 P21 S22 A77 I80 T81 H120 N121 R124 Y125 S167 S169 L170
BS02 MG A D18 E20 D14 E16
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywu, PDBe:5ywu, PDBj:5ywu
PDBsum5ywu
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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