Structure of PDB 5ywt Chain A

Receptor sequence
>5ywtA (length=222) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQA
LLQWVDEHARPFSTVKPMYGTP
3D structure
PDB5ywt Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 G23 L24 I84 H124 N125 R128 Y129 A157 K160 S176 Y177 S178 L179 H195 E16 A17 G19 L20 I80 H120 N121 R124 Y125 A153 K156 S162 Y163 S164 L165 H181
BS02 MG A D18 E20 D200 D14 E16 D186
BS03 CO A K211 P212 Q213 A214 K197 P198 Q199 A200
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywt, PDBe:5ywt, PDBj:5ywt
PDBsum5ywt
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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