Structure of PDB 5yws Chain A

Receptor sequence
>5ywsA (length=231) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTL
LSICQWKPQALLQWVDEHARPFSTVKPMYGT
3D structure
PDB5yws Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 L24 S26 I84 H124 N125 R128 Y129 R174 S176 Y177 S178 L179 H195 E16 A17 L20 S22 I80 H120 N121 R124 Y125 R170 S172 Y173 S174 L175 H191
BS02 MG A D18 E20 D200 D14 E16 D196
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5yws, PDBe:5yws, PDBj:5yws
PDBsum5yws
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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