Structure of PDB 5ywg Chain A

Receptor sequence

>5ywgA (length=366) Species: 3702 (Arabidopsis thaliana)

FSKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDL
STGNMVHASYLLTSGDLRFLFTAPYSPSLTASIPSFDHGSCRSFFSSHGL
GVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVL
RYVSYKAFLPGFERVEDAFPLDYGIRRLDHAVGNVPELGPALTYVAGFTG
FHQFAEFSGLNSAVLASNDEMVLLPINEPVKSQIQTYLEHNEGAGLQHLA
LMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIK
ECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMQSGGCGG
FGKGNFSELFKSIEEY

3D structure

• PDB: 5ywg Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations.
• Chain: A
• Resolution: 2.603 Å

Enzymatic activity

• Enzyme Commision number: 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO	A	H226 H308 E394	H180 H248 E334
BS02	92L	A	H226 S267 P280 H308 F381 F392 F419 G420 K421 F424	H180 S212 P225 H248 F321 F332 F351 G352 K353 F356

Gene Ontology

Molecular Function

• GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
• GO:0005506 iron ion binding
• GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006559 L-phenylalanine catabolic process
• GO:0006572 tyrosine catabolic process
• GO:0009072 aromatic amino acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5ywg, PDBe:5ywg, PDBj:5ywg
• PDBsum: 5ywg
• PubMed: 30632699
• UniProt: P93836|HPPD_ARATH 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)