Structure of PDB 5yw5 Chain A

Receptor sequence
>5yw5A (length=178) Species: 263 (Francisella tularensis) [Search protein sequence]
DDKMNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQEL
KNKGIQPTIVAGTESRGFIFGVALAEVLGLGFVPVRKPGKLPRATYSVKY
DLEYGSDSLEIHQDAFKVTDEVLVVDDLLATGGTAKATVDLIEKTQAKVA
GLIFVMELDGLGGREVLAGYNVSALIKF
3D structure
PDB5yw5 Crystal structures of APRT from Francisella tularensis - an N-H···N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.7: adenine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A F23 R24 F26 R27
Gene Ontology
Molecular Function
GO:0002055 adenine binding
GO:0003999 adenine phosphoribosyltransferase activity
GO:0016208 AMP binding
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006168 adenine salvage
GO:0009116 nucleoside metabolic process
GO:0044209 AMP salvage
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:5yw5, PDBe:5yw5, PDBj:5yw5
PDBsum5yw5
PubMed29694705
UniProtQ5NII9|APT_FRATT Adenine phosphoribosyltransferase (Gene Name=apt)

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