Structure of PDB 5yvh Chain A

Receptor sequence
>5yvhA (length=809) Species: 9606 (Homo sapiens) [Search protein sequence]
WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVL
TKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSP
LIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQK
ICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS
RTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHM
HNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVL
VNGMKYSDIDIIDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHH
EWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITC
WTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEE
EACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKP
EYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVY
QRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNI
EQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADF
MPILGTNLNPEFISVCNNATWAIGEISIQMMQPYIPMVLHQLVEIINRPN
TPKTLLENTAITIGRLGYVCPQQFIRPWCTSLRNIRDNEEKDSAFRGICT
MISVNPDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQRRFSDQFPLPL
KERLAAFYG
3D structure
PDB5yvh Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A A381 D384 W460 R495 S502 T506 E509 D543 G546 D550 E588 S591 D646 E653 D693 N726 N727 W730 N770 A322 D325 W401 R436 S443 T447 E450 D484 G487 D491 E529 S532 D587 E594 D634 N667 N668 W671 N708
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5yvh, PDBe:5yvh, PDBj:5yvh
PDBsum5yvh
PubMed29677513
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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