Structure of PDB 5yum Chain A

Receptor sequence
>5yumA (length=91) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
HDNVILELTVRNHPGVMTHVCGLFARRAFNVEGILCLPIQDSDKSHIWLL
VNDDQRLEQMISQIDKLEDVVKVQRNQSDPTMFNKIAVFFQ
3D structure
PDB5yum Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases.
ChainA
Resolution2.432 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.6: acetolactate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ILE A N19 H20 V23 M24 C43 N12 H13 V16 M17 C36 PDBbind-CN: -logKd/Ki=3.65,Ki=223uM
BS02 CO A H20 D76 H13 D69
Gene Ontology
Molecular Function
GO:0003984 acetolactate synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:1990610 acetolactate synthase regulator activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005948 acetolactate synthase complex

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Cellular Component
External links
PDB RCSB:5yum, PDBe:5yum, PDBj:5yum
PDBsum5yum
PubMed30887800
UniProtP0ADF8|ILVN_ECOLI Acetolactate synthase isozyme 1 small subunit (Gene Name=ilvN)

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