Structure of PDB 5yu8 Chain A

Receptor sequence
>5yu8A (length=360) Species: 9031 (Gallus gallus) [Search protein sequence]
TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHKDSYVGDEAQSKRGI
LTLKYPIEGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKAN
REKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPI
YEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEK
LCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPS
FIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQK
EITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEA
GPSIVHRKCF
3D structure
PDB5yu8 Structural basis for cofilin binding and actin filament disassembly
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G13 S14 G15 K18 G156 D157 R210 K213 E214 G301 G302 M305 Y306 G8 S9 G10 K13 G141 D142 R195 K198 E199 G286 G287 M290 Y291
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0030240 skeletal muscle thin filament assembly
GO:0048741 skeletal muscle fiber development
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament

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Cellular Component
External links
PDB RCSB:5yu8, PDBe:5yu8, PDBj:5yu8
PDBsum5yu8
PubMed29749375
UniProtP68139|ACTS_CHICK Actin, alpha skeletal muscle (Gene Name=ACTA1)

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