Structure of PDB 5yt3 Chain A

Receptor sequence
>5yt3A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHK
PSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE
ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH
RDVKPSNILVNSRGEIKLCDFGVTRSYMSPERLQYSVQSDIWSMGLSLVE
MAVGRYPIPPPDAKELELMFGPMAIFELLDYIVNEPPPKLPSGVFSLEFQ
DFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
3D structure
PDB5yt3 Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208 T226
Catalytic site (residue number reindexed from 1) D152 K154 N157 D170 T174
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A A76 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208 A38 V44 A57 K59 M105 M108 S112 Q115 D152 K154 S156 N157 L159 D170
BS02 MG A N195 D208 N157 D170
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5yt3, PDBe:5yt3, PDBj:5yt3
PDBsum5yt3
PubMed
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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