Structure of PDB 5yr4 Chain A

Receptor sequence
>5yr4A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKL
LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHA
QANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI
CEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARP
HFMS
3D structure
PDB5yr4 Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A D229 D240 E367 D140 D151 E278
BS02 CO A D240 H303 T334 E336 E367 D151 H214 T245 E247 E278
BS03 CO A Y195 H310 Y106 H221
BS04 TN4 A P192 Y195 H212 Y300 C301 M309 H310 E336 P103 Y106 H123 Y211 C212 M220 H221 E247 PDBbind-CN: -logKd/Ki=6.34,Ki=0.46uM
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5yr4, PDBe:5yr4, PDBj:5yr4
PDBsum5yr4
PubMed30837307
UniProtP53582|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)

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