Structure of PDB 5yp6 Chain A

Receptor sequence
>5yp6A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB5yp6 From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 I350 P500 E504 K72 Q82 I86 P236 E240
BS02 4CX A Q286 L287 W317 C320 H323 L324 R364 M365 R367 A368 V376 F377 F378 F388 L391 I397 I400 Q22 L23 W53 C56 H59 L60 R100 M101 R103 A104 V112 F113 F114 F124 L127 I133 I136 MOAD: ic50>0.0000316M
PDBbind-CN: -logKd/Ki=4.60,IC50>25uM
BindingDB: IC50=<25119nM,EC50=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5yp6, PDBe:5yp6, PDBj:5yp6
PDBsum5yp6
PubMed29456799
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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