Structure of PDB 5yno Chain A

Receptor sequence
>5ynoA (length=291) Species: 1235996 (Human betacoronavirus 2c EMC/2012) [Search protein sequence]
ASADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPVHMNIAKYMQLCQ
YLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNE
FVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFFTY
LCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSS
EGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQL
KLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTD
3D structure
PDB5yno Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A N43 Y47 G71 A72 G73 P80 D99 L100 D114 C115 D130 M131 Y132 N41 Y45 G69 A70 G71 P78 D97 L98 D112 C113 D128 M129 Y130
BS02 GTA A C25 L27 Y30 Y132 K137 K170 T172 E173 H174 S201 S202 C25 L27 Y30 Y130 K135 K168 T170 E171 H172 S199 S200
Gene Ontology
Molecular Function
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5yno, PDBe:5yno, PDBj:5yno
PDBsum5yno
PubMed
UniProtK0BWD0

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