Structure of PDB 5ynn Chain A

Receptor sequence
>5ynnA (length=295) Species: 1235996 (Human betacoronavirus 2c EMC/2012) [Search protein sequence]
ASADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQL
CQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDL
NEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFF
TYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANAS
SSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKF
QLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVL
3D structure
PDB5ynn Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A N43 G71 G73 D99 L100 D114 C115 D130 M131 N43 G71 G73 D99 L100 D114 C115 D130 M131
BS02 GTG A C25 E26 L27 Y30 Y132 P134 K137 T172 E173 H174 S201 S202 C25 E26 L27 Y30 Y132 P134 K137 T172 E173 H174 S201 S202
Gene Ontology
Molecular Function
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5ynn, PDBe:5ynn, PDBj:5ynn
PDBsum5ynn
PubMed
UniProtK0BWD0

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