Structure of PDB 5yle Chain A

Receptor sequence
>5yleA (length=331) Species: 562 (Escherichia coli) [Search protein sequence]
PKDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQ
LAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDT
LDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECR
DVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCE
GNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSD
HGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTH
DAITPTLLKLFDVTADKVKDRTAFIRLEHHH
3D structure
PDB5yle Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ETA A T70 N114 H180 T70 N114 H180
BS02 ZN A E31 T70 D250 H251 E31 T70 D250 H251
Gene Ontology
Molecular Function
GO:0016772 transferase activity, transferring phosphorus-containing groups

View graph for
Molecular Function
External links
PDB RCSB:5yle, PDBe:5yle, PDBj:5yle
PDBsum5yle
PubMed29079699
UniProtA0A0R6L508|MCR1_ECOLX Probable phosphatidylethanolamine transferase Mcr-1 (Gene Name=mcr1)

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