Structure of PDB 5ykp Chain A

Receptor sequence
>5ykpA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
PYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIK
LLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNC
YPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYH
GDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKH
AQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPM
ICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSAR
PHFMS
3D structure
PDB5ykp Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A D240 H303 T334 E336 E367 D152 H215 T246 E248 E279
BS02 CO A D229 D240 E367 D141 D152 E279
BS03 CO A E128 Y195 H310 E40 Y107 H222
BS04 OVA A P192 Y195 H212 Y300 C301 E336 P104 Y107 H124 Y212 C213 E248 PDBbind-CN: -logKd/Ki=7.05,Ki=0.09uM
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5ykp, PDBe:5ykp, PDBj:5ykp
PDBsum5ykp
PubMed30837307
UniProtP53582|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)

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