Structure of PDB 5yjg Chain A

Receptor sequence

>5yjgA (length=594) Species: 9606 (Homo sapiens) [Search protein sequence]

DQGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRME
GMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAP
SNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPS
MYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSI
QDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVL
ERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDS
ITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDL
VAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVK
VGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHI
FREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPT
NDAFKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKT
TQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPA

3D structure

PDB

5yjg Structural characterizations of human periostin dimerization and cysteinylation.

Chain

Resolution

2.399 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CYS	A	Q39 C60 Y64	Q2 C23 Y27
BS02	CA	A	D258 K294	D221 K257
BS03	CA	A	T176 K177	T139 K140
BS04	CA	A	N445 V571	N408 V534
BS05	MG	A	A110 T112 T113 P137 S138 N139	A73 T75 T76 P100 S101 N102
BS06	MG	A	L247 S249 F250 P274 T275 N276 F279	L210 S212 F213 P237 T238 N239 F242
BS07	MG	A	Q380 Q381 F384 P408 N410	Q343 Q344 F347 P371 N373
BS08	MG	A	F509 T511 F512 F541	F472 T474 F475 F504
BS09	MG	A	C208 C311 S312 E313 D350	C171 C274 S275 E276 D313
BS10	MG	A	E597 S612 D613	E560 S575 D576
BS11	MG	A	F195 N197 T205 N207 C208	F158 N160 T168 N170 C171

External links

PDB	RCSB:5yjg, PDBe:5yjg, PDBj:5yjg
PDBsum	5yjg
PubMed	29754429
UniProt	Q15063\|POSTN_HUMAN Periostin (Gene Name=POSTN)

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