Structure of PDB 5yh3 Chain A

Receptor sequence
>5yh3A (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
SSKLQALFAHPLYNVPEEPPLLGAEDSLLASQEALRYYRRKVARWNRRHK
MYREQMNLTSLDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDM
RHFPTISADYSQDEKALLGACDCTQIVKPSGVHLKLVLRFSDFGKAMFKP
MRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNV
TKEILEVTKNEILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGKPHLLEG
SLSAFLPSLNLAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYN
NSQRLLNVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRH
SHDEISILSPLSQCCMIKKKTLLHLQLLAQADYRLSDVMRESLLEDQLSP
VLTEPHLLALDRRLQTILRTVEGCIVAHGQQSVIVDGP
3D structure
PDB5yh3 Structure and evolution of the Fam20 kinases
ChainA
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y125 K129 K233 M235 P279 S341 F343 S346 R352 Y37 K41 K145 M147 P191 S253 F255 S258 R264
BS02 ATP A K129 R132 R136 Y140 D197 K203 K297 N298 E299 K41 R44 R48 Y52 D109 K115 K209 N210 E211
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0009617 response to bacterium
GO:0031214 biomineral tissue development
GO:0044691 tooth eruption
GO:0055074 calcium ion homeostasis
GO:0070166 enamel mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5yh3, PDBe:5yh3, PDBj:5yh3
PDBsum5yh3
PubMed29572475
UniProtQ96MK3|FA20A_HUMAN Pseudokinase FAM20A (Gene Name=FAM20A)

[Back to BioLiP]