Structure of PDB 5yf1 Chain A

Receptor sequence
>5yf1A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
EEERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFL
LHLDKIRKCIDHNQEILLTIVNDCIHKIMPASTFDMDKLKSTLKQFVRDW
SETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIA
MLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQ
IRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAH
NVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVL
QYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
3D structure
PDB5yf1 Molecular basis for histidine N1 position-specific methylation by CARNMT1.
ChainA
Resolution2.399 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.22: carnosine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A R167 Y181 G208 E229 W230 F296 C312 F313 F314 T317 Y324 Y386 R98 Y112 G139 E160 W161 F227 C243 F244 F245 T248 Y255 Y317
BS02 8V0 A F313 D316 H347 Y386 Y396 Y398 F244 D247 H278 Y317 Y327 Y329 MOAD: Kd=0.52mM
PDBbind-CN: -logKd/Ki=3.28,Kd=0.52mM
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5yf1, PDBe:5yf1, PDBj:5yf1
PDBsum5yf1
PubMed29463897
UniProtQ8N4J0|CARME_HUMAN Carnosine N-methyltransferase (Gene Name=CARNMT1)

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