Structure of PDB 5yf0 Chain A

Receptor sequence
>5yf0A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
RLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHL
DKIRKCIDHNQEILLTIVNDCIKIMPASTFDMDKLKSTLKQFVRDWSETG
KAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGY
ACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPI
FFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVID
YIDTIWKILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGF
KVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
3D structure
PDB5yf0 Molecular basis for histidine N1 position-specific methylation by CARNMT1.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.22: carnosine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A R167 Y181 G208 E229 W230 M234 D295 F296 C312 F313 F314 T317 Y324 Y386 R94 Y108 G135 E156 W157 M161 D222 F223 C239 F240 F241 T244 Y251 Y313
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5yf0, PDBe:5yf0, PDBj:5yf0
PDBsum5yf0
PubMed29463897
UniProtQ8N4J0|CARME_HUMAN Carnosine N-methyltransferase (Gene Name=CARNMT1)

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