Structure of PDB 5yew Chain A

Receptor sequence
>5yewA (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
VSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDL
VEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSG
IGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKVNNQLAHALHMDKDLKA
GCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVL
VANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRR
QHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAALAEGFHA
RLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAA
EDLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLP
3D structure
PDB5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
ChainA
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A S85 G87 K88 S89 S90 S103 G104 N237 R238 D240 S284 K286 S81 G83 K84 S85 S86 S99 G100 N233 R234 D236 S280 K282
BS02 BEF A T84 H107 I108 T109 G181 T80 H103 I104 T105 G177
BS03 K A S85 G104 I105 G106 H107 I108 S81 G100 I101 G102 H103 I104
BS04 MG A S89 T109 D178 S85 T105 D174
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5yew, PDBe:5yew, PDBj:5yew
PDBsum5yew
PubMed29483649
UniProtQ8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

[Back to BioLiP]