Structure of PDB 5yeh Chain A

Receptor sequence

>5yehA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]

KPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHM
RTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIAR
KSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQK

3D structure

PDB

5yeh Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites

Chain

Resolution

2.328 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Y358 E362 R368 S372 R377 Y386 R389 K393 R396 H397 T400 F416 T417 Q418 H425 K429 T444 A447 R448 D451 Q459	Y10 E14 R20 S24 R29 Y38 R41 K45 R48 H49 T52 F68 T69 Q70 H77 K81 T96 A99 R100 D103 Q111
BS02	dna	A	E362 Y392 K395 K423 K449 S450 R457	E14 Y44 K47 K75 K101 S102 R109
BS03	dna	A	H441 C442	H93 C94
BS04	ZN	A	C353 C356 H369 H373	C5 C8 H21 H25
BS05	ZN	A	C381 C384 H397 H401	C33 C36 H49 H53
BS06	ZN	A	C409 C412 H425 H430	C61 C64 H77 H82
BS07	ZN	A	C439 C442 H455 H460	C91 C94 H107 H112
BS08	ZN	A	C469 Y471 C472 H485	C121 Y123 C124 H137

External links

PDB	RCSB:5yeh, PDBe:5yeh, PDBj:5yeh
PDBsum	5yeh
PubMed	29076501
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)