Structure of PDB 5yeg Chain A

Receptor sequence

>5yegA (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]

PFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMR
THSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARK
SDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQK

3D structure

PDB

5yeg Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites

Chain

Resolution

2.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S364 Y392 K449 S450 R457	S15 Y43 K100 S101 R108
BS02	dna	A	Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 Q418 T421 H425 K429 I446 A447 R448 D451 H455 Q459 R479	Y9 E13 K16 R19 H20 S23 R28 Y37 R40 K44 R47 H48 Q69 T72 H76 K80 I97 A98 R99 D102 H106 Q110 R130
BS03	dna	A	H441 C442	H92 C93
BS04	ZN	A	C353 C356 H369 H373	C4 C7 H20 H24
BS05	ZN	A	C409 C412 H425 H430	C60 C63 H76 H81
BS06	ZN	A	C439 C442 H455 H460	C90 C93 H106 H111
BS07	ZN	A	C381 C384 H397 H401	C32 C35 H48 H52
BS08	ZN	A	C469 C472 H485	C120 C123 H136

External links

PDB	RCSB:5yeg, PDBe:5yeg, PDBj:5yeg
PDBsum	5yeg
PubMed	29076501
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)